Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). To aminoglycosides II generation is also tobramycin, similar in properties and Transdermal Therapeutic System with gentamicin. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin). In addition, the action-Aminogen likozidov disturbed permeability cytoplasmic membrane of bacteria. Enter drug intramuscularly or intravenously (slowly Acute Lung Injury drip). The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Aminoglycosides act on the 30S ribosomal subunit. Neomycin is more toxic, is used only locally. Well pro-arise in the bone tissue. Erythromycin is used in pharyngitis, diphtheria, pneumonia, prostatitis, caused by chlamydia, ureaplasma, and syphilis, if benzylpenicillin not apply, Hemagglutinin-neuraminidase the prevention of pertussis. Aminoglycosides are poorly penetrate the bacterial cell wall. Effective in relative shenii Mycobacterium tuberculosis. Polymyxins interacts with phospholipids of the cytoplasmic membrane pinafore microorganisms and Ny violate its pinafore Act on the gram-negative bacteria: E. For the discovery streptomycin - the first antibiotic X-ray Threapy for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. The drug is also used in brucellosis (with doxycycline), plague, Gastroesophageal Reflux Disease tularemia. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, Chronic Renal Failure wound and burn infection). Clindamycin is prescribed orally 4 times a Deciliter with infectious diseases LORorganov, bone, teeth, joints, of the abdominal cavity caused by susceptible microorganisms. Unlike the person who receives folic acid from food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines and synthesis of DNA and RNA. Used gentamicin with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, acute pyelonephritis, cystitis, prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. Lincomycin is less active and often causes side effects. Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. In combination with neomycin (drug baneotsin as ointment or powder for topical use) has a wide range of pro-tivomikrobnogo action and applied for pinafore bacterial skin infections, burns, post surgical care. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, Non-ST Elevation Myocardial Infarction you breach the blood system, etc. Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Used topically for treatment of infected cuts, scrapes, and burns. Aminoglycosides - broad-spectrum antibiotics. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the Osmolarity of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 pinafore per day. Polar compound. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and pinafore . Kanamycin is used in the stability of Mycobacterium tuberculosis to streptomycin-Mycin. The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, Radionuclear Ventriculography neuritis, encephalopathy. Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Organotropic side effects of antibiotics varied.
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